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cyclosporine will enhance the stage or outcome of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.levoketoconazole will improve the amount or influence of bortezomib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Observe Intently (1)bortezomib will boost the level or effect of